The latest CryptoDredge Nvidia GPU miner version 0.14.0 comes with support for the new Lyra2REv3 algorithm as well as improved performance for X22i used by the SUQA project, faster Skunkhash and X16-based algorithms. The new Lyra2REv3 algorithm is going to be used by Vertcoin (VTC) as a means to avoid the use of the recently made available ASICs for the currently used Lyra2REv2 algorithm. VTC is currently running on testnet with the new algorithm with mainnet fork to Lyra2REv3 coming soon if everything is fine with the testnet release and there are not problems.
With the latest release you can expect to get up to 10-12% performance boost for the X22i algorithm, up to 2-4% for Skunkhash and up to 5-7% performance increase for the X16-based algorithms, so definitely worth upgrading for the extra performance. Do note that the CryptoDredge miner supports only Nvidia GPUs and is a closed source software that comes with 1% built-in developer fee and with binaries available for both Windows and Linux (CUDA 9.1/9.2/10.0).